Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075

The clinical relevance of this finding is unknown and should be further explored. These data show that S1 antigen production after the initial vaccination can be detected by day one and is present beyond the site of injection and the associated regional lymph nodes. Induction of IgG and IgA immune responses can be detected as early as day five post vaccination and are associated with clearance of spike and S1 antigen in the systemic circulation.